Identification of vascular postsynaptic alpha 1- and alpha 2-adrenoceptors in man.

Alpha 1-adrenoceptors in human corneal epithelium.

Specific binding of the potent, selective alpha 1-adrenoceptor antagonist 3H-prazosin was demonstrated in cultured human corneal epithelial cells. Specific binding of the radioligand was concentration-dependent between 0.5 and 6 nM, with apparent saturation of receptor sites seen at higher concentrations. The cells exhibited a maximum binding capacity for 3H-prazosin of 225 fmol/mg of cellular ...

Heterogeneity of human vascular pre- and post-synaptic alpha-adrenoceptors.

Involvement of alpha-1 and alpha-2 adrenoceptors in the postlaparotomy intestinal motor disturbances in the rat.

The effects of phentolamine, yohimbine and prazosin on laparotomy induced intestinal motor disturbances were studied in anaesthetised fasted rats previously equipped with electrodes, chronically implanted on the duodenum and jejunum. During continuous recording of interdigestive myoelectric activity, laparotomy under thiopental anaesthesia (Nesdonal 40 mg/kg ip) induced a primary phase of total...

Thrombocyte alpha-2-adrenoceptors and hypotension in hemodialyzed patients.

PD Dr. Friendrich Lübbecke , Zentrum für Innere Medizin, Medizinische Klinik II, Dlinikstr. 36, D-35392 Giessen (Germany) Dear Sir, The clinical problem of hemodialysis-as-sociated hypotension has partially been resolved by lowering ultrafiltration rates in hypotension-prone patients. However, the mechanisms leading to hypotensive circulatory states during hemodialysis or in the inter-dialytic ...

Uneven distribution of postjunctional alpha 1-and alpha 2-like adrenoceptors in canine arterial and venous smooth muscle.

We studied isolated canine arteries and veins to compare the pharmacological properties of their postjunctional alpha-adrenoceptors. Rings of femoral and splenic arteries and of femoral and saphenous veins were mounted for isometric tension recording in organ chambers filled with Krebs-Ringer bicarbonate solution. The four blood vessels contracted when exposed to methoxamine, norepinephrine, ph...